The diagnosis of such patients is made by a biopsy, which is performed in addition to clinical and radiological evaluation. Although blood tests do not make a definitive diagnosis, they can support our diagnosis (Alkaline phosphatase and Lactic dehydrogenase height) and are used in the differential diagnosis from other lesions such as bone infection (CRP height). Radiologically, direct graphy (simple x-ray) is a must-have and medicated (contrast-enhanced) MRI is one of our routine examinations. We perform the biopsy procedure under anesthesia in the operating room with the help of a needle, often closed, accompanied by imaging (scopy). An experienced bone pathologist plays a vital role in evaluating the biopsy taken. Additional bone scintigraphy and lung tomography techniques are required for staging (whether there are other bone or lung metastases) from patients who have been diagnosed.

A patient who has been diagnosed and screened is referred to medical oncology and given chemotherapy. (Chemotherapy is effective only for some types of chondrosarcoma patients while routine chemotherapy is given in osteosarcoma and Ewing's sarcoma) Control X-ray and MRI are taken from the patient who has finished chemotherapy and the surgery is performed. During the surgery, the cancerous bone is removed and replaced with a prosthesis, as well as the cavity can be filled with bone taken from himself/herself (fibula), or the removed bone with tumor is cleaned and put in place with an implant/plaque after undergoing some procedures (liquid nitrogen or radiotherapy). After the surgery, the patient whose wound site has healed is referred to the medical oncology unit for chemotherapy again.